Live Events

Multi-System Manifestations of Progressive Brain Diseases

8:00 AM PDT
Multi-System Manifestations of Progressive Brain Diseases CME
Multi-system Manifestations of Progressive Brain Diseases

June 12, 2021, 8:00 am - 3:00 pm PDT




Most progressive brain diseases – including Parkinson’s disease, Alzheimer’s disease, multiple sclerosis, amyotrophic lateral sclerosis, and Huntington’s disease – occur as a result of neurodegenerative processes. The progressive degeneration and/or death of neuronal and glia cells cause a number of symptoms years before a clinical diagnosis, many of which can help recognize prodromal states. Symptoms originating from various organ systems are not usually recognized as cardinal for the definition and/or diagnosis of these diseases. While these often highly disabling, multi-system manifestations of neurodegenerative diseases are commonly neglected, their appropriate treatment can markedly improve patients’ quality of life. This conference will focus on the disabilities caused by motor, autonomic, enteric, and neuropsychiatric decline as a result of neurodegenerative diseases.


Target Audience 

This activity is intended for neurologists, primary care physicians, psychiatrists, psychologists, physician assistants, nurse practitioners, nurses, physical and occupational therapists and other allied health professionals who care for patients with neurological disorders.


Deadline for Registration & Cancellation

Register at Preregistration is accepted online until 3:00 pm (PST) Thursday, JUNE 10, 2021. A full refund will be made if email notification is received by JUNE 10, 2021. NO REFUNDS WILL BE GIVEN AFTER JUNE 10. For questions about registration, please call 216.448.8710 or email

Americans With Disabilities Act

The Cleveland Clinic Foundation Center for Continuing Education fully intends to comply with the legal requirements of the Americans with Disabilities Act. If you need assistance, please notify LeeAnn Mandarino at 702.483.6024 at least two weeks prior to the activity.



Faculty Disclosure Statement

The Cleveland Clinic Foundation Center for Continuing Education has implemented a policy to comply with the current Accreditation Council for Continuing Medical Education Standards for Commercial Support requiring resolution of all faculty conflicts of interest. Faculty declaring a relevant commercial interest will be identified in the activity syllabus.



For additional information, please contact LeeAnn Mandarino at 702-483-6024 |

Activity Director

Activity Co-Director

Zoltan Mari, MD

Neurology and Neurophysiology
Director, Parkinson's Disease and Movement Disorders Program
Ruvo Family Chair and Director

Dr. Zoltan Mari is a board-certified neurologist, fellowship-trained in movement disorders at the National Institutes of Health. He is an internationally recognized Parkinson and movement disorder specialist, who directed the Johns Hopkins Movement Disorder Center before joining Cleveland Clinic. Dr. Mari authored 100 peer-reviewed articles and serves in multiple leadership roles in international Parkinson & movement disorder journals and professional organizations. Dr. Mari is Co-Director of the Cleveland Clinic Parkinson’s Foundation Center of Excellence.

Dylan Wint, MD

Neurology and Psychiatry
Director Cleveland Clinic Lou Ruvo Center for Brain Health
Las Vegas Legacy Neuroscience Education Endowed Chair

Dr. Wint earned his undergraduate and medical degrees at Stanford University and the University of Miami. His postgraduate training includes residencies in Neurology and Psychiatry, a research fellowship, and a deep brain stimulation fellowship at the University of Florida; and an integrated neuroimaging fellowship at the National Institutes of Health. As a faculty member at Emory University, he developed a clinical, research, and educational unit dedicated to optimizing the understanding, diagnosis, and treatment of behavioral problems in patients with neurologic illnesses.

Since 2010, Dr. Wint has directed the Education Department at Cleveland Clinic Lou Ruvo Center for Brain Health. The department provides learning and mentorship opportunities for K-12, college, and professional students; has started four fellowship programs; offers educational programs for patients, caregivers, and the general community; and presents multiple interdisciplinary continuing education programs for medical professionals.

Cleveland Clinic Faculty

Lucille Carriere, PhD

Clinical Psychology and Health Psychology
Angie Ruvo Endowed Caregiver Chair

Dr. Lucille Carriere is a clinical psychologist specializing in health psychology. She completed her graduate training at Auburn University, an internship through Vanderbilt University and the Veterans Affairs Medical Center in Nashville, TN, and a fellowship at the Cleveland Clinic’s Mellen Center for Multiple Sclerosis. Prior to joining the Lou Ruvo Center for Brain Health, she worked in geriatric primary care and provided psychotherapy for individuals and caregivers living with neurodegenerative disorders and complex medical conditions. She is interested in outcomes research related to caregivers.

Le Hua, MD

Neurology and Neuroimmunology
Director, Mellen Program for Multiple Sclerosis
Eric and Sheila Smason Chair for Multiple Sclerosis Research

Le Hua, MD is the Director of the Multiple Sclerosis Program at the Cleveland Clinic Lou Ruvo Center for Brain Health in Las Vegas, NV. Dr. Hua earned her MD at Keck School of Medicine at the University of Southern California. Subsequently, she completed her internship at Banner Good Samaritan Medical Center in Phoenix and her neurology residency at Stanford University School of Medicine. She went on to complete a clinical fellowship in Neuro-Immunology and MS at the Barrow Neurological Institute and St. Joseph’s Hospital and Medical Center in Phoenix.

Dr. Hua is involved in clinical trials assessing new therapies for the treatment of MS and her personal research interests include using advanced MRI techniques to study MS and neurological disorders, as well as aging and cognition in MS.

Shaina Meyer, OTR/L

Occupational Therapy
Manager, Rehabilitation Services

Shaina Meyer received her bachelor’s degree in psychology with an emphasis in biology from Westminster College in Missouri and a master’s in occupational therapy from St. Louis University. While at the Lou Ruvo Center for Brain Health, Ms. Meyer has become a Parkinson Wellness Recovery (PWR!) Certified therapist, Multiple Sclerosis Certified Specialist, Certified Dementia Practitioner, and has spoken at the Neurotherapeutics for Rehabilitation course.

Odinachi Oguh, MD

Associate Staff
Neurology and Movement Disorders

Dr Odinachi Oguh is a board certified movement disorder neurologist. She graduated summa cum laude from her medical school, finished her neurology residency at the University of Illinois and a post graduate movement disorder fellowship at Northwestern University. Prior to joining Cleveland Clinic in 2019, she spearheaded the Movement Disorders Program at the University of Florida, focusing on clinical research programs, deep brain stimulation pre-surgical evaluation, Botox management and community outreach. Dr. Oguh’s research interests lie in novel drug targets for Parkinson’s disease.

Kelly Papesh, DNP

Nurse Practitioner
Manager, Advanced Practice Providers

Kelly received her doctorate in nursing practice in 2018. She is a certified family nurse practitioner working with the Movement Disorders team at the Cleveland Clinic Lou Ruvo Center for Brain Health.  She manages patients with Parkinson’s disease, tremor, Huntington’s disease, and ataxia among other movement disorders.  She has skilled training in management of advanced procedures such as botulinum toxin injections, deep brain stimulation, and Duopa.  She is passionate about caring for her patients and helping them in their journey to find their best individualized treatment; and she believes providing education and outreach are the foundation to making an impact on the community.  Kelly is a member of the Movement Disorders Society and American Academy of Neurology.

Aaron Ritter, MD

Associate Staff
Neuropsychiatry and Behavioral Neurology

Dr. Aaron Ritter is originally from northern Colorado. His medical training and academic career has focused on the intersection of neurology and psychiatry. He has completed training primarily at institutions focused on this including: medical school (University of Colorado); residency and internship (University of Arizona); and fellowship in behavioral neurology and neuropsychiatry (Cleveland Clinic Lou Ruvo Center for Brain Health). He has been a clinical staff at the Cleveland Clinic since 2016 and has been heavily involved in the clinical trials program. His research interests include clinical trials for Alzheimer’s disease, atypical neurodegenerative syndromes, and chronic traumatic encephalopathy (CTE).

Marwan Sabbagh, MD, FAAN

Neurology and Geriatric Neurology
Director of Translational Research
Camille and Larry Ruvo Endowed Chair for Brain Health

Marwan Noel Sabbagh, MD, board certified neurologist and geriatric neurologist, hopes to work himself out of a job. Considered one of the leading experts in Alzheimer’s and dementia, Dr. Sabbagh has dedicated his entire career to finding a cure for Alzheimer’s and other age-related neurodegenerative diseases.

Dr. Sabbagh is a leading investigator for many prominent national Alzheimer’s prevention and treatment trials, including Alzheimer immunotherapy studies. He is on the editorial board for Journal of Alzheimer’s Disease and BMC Neurology. He is now editor-in-chief of Neurology and Therapy. He has authored and co-authored over 300 medical and scientific articles on Alzheimer’s research. 

Dr. Sabbagh is the author of The Alzheimer’s Answer: Reduce Your Risk and Keep Your Brain Healthy, with foreword by Justice Sandra Day O’Connor, and The Alzheimer’s Prevention Cookbook: 100 Recipes to Boost Brain Health. He edited Palliative Care for Advanced Alzheimer’s and Dementia: Guidelines and Standards for Evidence Based Care and Geriatric Neurology, published in 2014.

Dr. Sabbagh earned his undergraduate degree from the University of California, Berkeley and his medical degree from the University of Arizona in Tucson. He received his residency training in neurology at Baylor College of Medicine, Houston, Texas, and completed his fellowship in geriatric neurology and dementia at the University of California, San Diego School of Medicine, where he served on the faculty as assistant professor. Before joining the faculty of the Barrow Neurological Institute where he served for three years, Dr. Sabbagh was with the Banner Sun Health Research Institute for 15 years.

Guest Faculty

Eric Farbman, MD

Neurology and Movement Disorders
Roseman Medical Group, Roseman University of Health Sciences

Dr. Farbman received his Master of Science degree from Tufts University and went on to receive his MD from Rutgers University Medical School and a Movement Disorders Fellowship at the University of Pittsburgh. He is currently a physician at Roseman University Medical Center specializing in Movement Disorders, treating Parkinson’s, Huntington’s, dystonia, ataxias and tremors.

Planning Committee

LeeAnn Mandarino, MA

Conference Organizer
Manager, Education in Neurodegeneration
Manager, Professional Education Programs


8:00 am - 8:15 am
Introduction - Pre-test
Zoltan Mari, MD
8:15 am - 8:30 am
Introduction to Alzheimer's disease and other degenerative dementias
Aaron Ritter, MD
8:30 am - 8:45 am
Introduction to multiple sclerosis and other neuroimmonological diseases
Le Hua, MD
8:45 am - 9:00 am
Introduction to Parkinson's disease and other movement disorders
Odinachi Oguh, MD
9:00 am - 9:15 am
15 minute break
9:15 am - 9:45 am
Visual, auditory, and somatosensory impairment in neurodegenerative disorders
Le Hua, MD
9:45 am - 10:15 am
Cardiovascular, urinary and other autonomic manifestations of neurodegenerative disorders
Kelly Papesh, DNP
10:15 am - 10:45 am
The role of OT, PT and SLP in neurodgenerative disorders
Shaina Meyer, OTR/L
10:45 am - 11:00 am
15 minute break
11:00 am - 11:30 am
Gastrointestinal symptoms and nutritional considerations in neurodgenerative disorders
Odinachi Oguh, MD
11:30 am - 12:00 pm
Pain management in neurodgenerative disorders
Eric Farbman, MD
12:00 pm - 12:30 pm
Sleep disorders in neurodegenerative disorders
Lucille Carriere, PhD
12:30 pm - 1:00 pm
30 minute break
1:00 pm - 1:30 pm
Psychosis in neurodegenerative disorders
Dylan Wint, MD
1:30 pm - 2:00 pm
Anxiety and depression in neurodegenerative disorders
Aaron Ritter, MD
2:00 pm - 2:30 pm
Mild cognitive impairment and dementia in neurodegenerative disorders
Marwan Sabbagh, MD, FAAN
2:30 pm - 3:00 pm
Spasticity, ridigidty, and other motor symptoms in neurodegenerative disorders
Zoltan Mari, MD
3:00 pm - 3:00 pm
Post-test and Adjourn


Upon completion of this program, participants will be able to:
1. Evaluate and manage neuropsychiatric disability in neurodegenerative disorders.
2. Identify and treat disorders of the autonomic and enteric nervous system in neurodegenerative disorders.
3. Identify and manage motor symptoms in neurodegenerative disorders.
4. Recognize the impact of multidisciplinary care in neurodegenerative disorders.

Disclosures and Accreditation Statement

The Cleveland Clinic Foundation Center for Continuing Education is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

The Cleveland Clinic Foundation Center for Continuing Education designates this internet live activity for a maximum of 6 AMA PRA Category 1 CreditsTM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Participants claiming CME credit from this activity may submit the credit hours to the American Osteopathic Association Council for Category 2 credit.

This course has been submitted to the State of Nevada Physical Therapy Examiners Board for 6 hours of continuing education. Approval is pending.